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HYDROMORPHONE HYDROCHLORIDE, Ampul, Vial, Carpuject™, iSecure™ U.S. Physician Prescribing Information (hydromorphone hydrochloride injection, USP) Patient Counseling Information

17 PATIENT COUNSELING INFORMATION

Serotonin Syndrome

Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop. Instruct patients to inform their physicians if they are taking, or plan to take serotonergic medications. [see Drug Interactions 7].

Constipation

Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention [see Adverse Reactions (6)].

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